A phylogenetic estimator of effective population size or mutation rate.
نویسندگان
چکیده
منابع مشابه
A phylogenetic estimator of effective population size or mutation rate.
A new estimator of the essential parameter theta = 4Ne mu from DNA polymorphism data is developed under the neutral Wright-Fisher model without recombination and population subdivision, where Ne is the effective population size and mu is the mutation rate per locus per generation. The new estimator has a variance only slightly larger than the minimum variance of all possible unbiased estimators...
متن کاملEstimating effective population size or mutation rate with microsatellites.
Microsatellites are short tandem repeats that are widely dispersed among eukaryotic genomes. Many of them are highly polymorphic; they have been used widely in genetic studies. Statistical properties of all measures of genetic variation at microsatellites critically depend upon the composite parameter theta = 4Nmicro, where N is the effective population size and micro is mutation rate per locus...
متن کاملThe effects of variable mutation rates across sites on the phylogenetic estimation of effective population size or mutation rate of DNA sequences.
Multiple hits at some sites of human mitochondrial DNA sequences suggest that the commonly assumed infinite-sites model can be violated. Under the neutral Wright-Fisher model without recombination and population subdivision, we investigated, by computer simulations, the effect of multiple hits on the estimation of the essential parameter theta = 4Nmu by FU's UPBLUE procedure. We found that with...
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Amounts of genetic drift and the effective size of populations can be estimated from observed temporal shifts in sample allele frequencies. Bias in this so-called temporal method has been noted in cases of small sample sizes and when allele frequencies are highly skewed. We characterize bias in commonly applied estimators under different sampling plans and propose an alternative estimator for g...
متن کاملPhylogenetic effective sample size.
In this paper I address the question-how large is a phylogenetic sample? I propose a definition of a phylogenetic effective sample size for Brownian motion and Ornstein-Uhlenbeck processes-the regression effective sample size. I discuss how mutual information can be used to define an effective sample size in the non-normal process case and compare these two definitions to an already present con...
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ژورنال
عنوان ژورنال: Genetics
سال: 1994
ISSN: 1943-2631
DOI: 10.1093/genetics/136.2.685